Across TCGA patient cohorts, STYXL2 mutation is significantly associated with the RNA expression of many other genes, with 6,198 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STYXL2-associated genes across cancer lineages are HMG20B, PIP4K2C, and GPATCH3. Each is linked with STYXL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both STYXL2-to-partner and partner-to-STYXL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STYXL2→partner) and Y-score (partner→STYXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMG20B →	+0.421	+1.357	<.001	.003	3	5
SKCM	PIP4K2C →	+0.292	+1.457	.004	<.001	3	4
SKCM	GPATCH3 →	+0.270	+1.353	<.001	<.001	3	4
LUAD	E2F1 →	+0.695	+3.918	<.001	<.001	3	4
LUAD	PIMREG →	+0.620	+1.655	.002	.002	3	4
LUAD	KIF2C →	+0.811	+2.502	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,198 associations by consensus.

Exploration

STYXL2 survival (RNA) · tumor vs normal (RNA) · all STYXL2 data types