STYK1

Across TCGA cell cohorts, STYK1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible STYK1-associated genes across cancer lineages are SPINK9, PPP1R17, and GSG1L2. Each is linked with STYK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STYK1-to-partner and partner-to-STYK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by STYK1-low versus STYK1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STYK1→partner) and Y-score (partner→STYK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	1
LARGE_INTESTINE	PPP1R17 →	+0.055	+4.467	.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1
BLOOD_Leukemia	ALPI →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SMIM23 →	+0.030	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SPINK9 by STYK1 expression — SKIN

Explore this box plot interactively →