STXBP6

Across TCGA patient cohorts, STXBP6 protein abundance is significantly associated with the RNA expression of many other genes, with 9,876 significant associations in total. GBM shows the largest number of these associations.

The most reproducible STXBP6-associated genes across cancer lineages are SH3BGRL2, SSTR1, and PAK5. Each is linked with STXBP6 in more than 5 cancer types. Because this analysis shows association rather than direction, both STXBP6-to-partner and partner-to-STXBP6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STXBP6 versus SH3BGRL2 in HNSC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP6→partner) and Y-score (partner→STXBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3BGRL2 →	+1.311	+0.503	<.001	<.001	3	6
PDAC	SSTR1 →	+0.677	+0.369	<.001	<.001	3	5
GBM	PAK5 →	+1.077	+0.819	<.001	<.001	3	5
OV	DCAF11 →	+0.396	+0.849	<.001	.001	3	4
COAD	CEP70 →	+0.750	+0.537	<.001	.001	3	4
COAD	MRAP2 →	+1.243	+0.545	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,876 associations by consensus.

STXBP6 vs SH3BGRL2 — HNSC

Explore this scatter interactively →