STXBP6

Across TCGA patient cohorts, STXBP6 mutation is significantly associated with the RNA expression of many other genes, with 973 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP6-associated genes across cancer lineages are RNA5SP222, LARP1BP3, and RPS15AP32. Each is linked with STXBP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both STXBP6-to-partner and partner-to-STXBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP222 grouped by STXBP6-low versus STXBP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP6→partner) and Y-score (partner→STXBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP222 →	+0.245	+3.555	<.001	<.001	3	3
UCEC	LARP1BP3 →	+0.083	+2.449	<.001	.007	3	3
LUAD	RPS15AP32 →	+0.174	+5.327	<.001	.002	3	2
UCEC	RNU1-14P →	+0.215	+2.316	<.001	.004	3	2
UCEC	RNU1-68P →	+0.064	+3.069	<.001	.005	3	2
UCEC	MIR3198-1 →	+0.515	+1.590	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 973 associations by consensus.

RNA5SP222 by STXBP6 expression — UCEC

Explore this box plot interactively →