STXBP6

Across TCGA cell cohorts, STXBP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,153 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STXBP6-associated GO terms across cancer lineages are Regulation of lamellipodium morphogenesis, Regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion, and Negative regulation of nervous system process. Each is linked with STXBP6 in more than 6 cancer types. Because this analysis shows association rather than direction, both STXBP6-to-partner and partner-to-STXBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of lamellipodium morphogenesis grouped by STXBP6-low versus STXBP6-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP6→partner) and Y-score (partner→STXBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of lamellipodium morphogenesis →	+0.122	+2.094	.002	.002	3	7
LUNG_NSCLC_LUSC	Regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion →	-0.167	-2.008	.002	.005	2	7
SOFT_TISSUE	Negative regulation of nervous system process →	+0.160	+2.095	<.001	<.001	2	7
BLOOD_Leukemia	Adherens junction maintenance →	+0.418	+1.236	.003	<.001	3	6
LIVER	Copulation →	+1.467	+1.802	.004	.005	3	6
BLOOD_Leukemia	Midbrain dopaminergic neuron differentiation →	-0.093	-1.002	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,153 associations by consensus.

Regulation of lamellipodium morphogenesis by STXBP6 expression — URINARY_TRACT

Explore this box plot interactively →