STXBP5L

Across TCGA patient cohorts, STXBP5L mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP5L-associated genes across cancer lineages are STAT3_pY705, Ku80, and JNK_pT183_Y185. Each is linked with STXBP5L in more than 3 cancer types. Because this analysis shows association rather than direction, both STXBP5L-to-partner and partner-to-STXBP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by STXBP5L-low versus STXBP5L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP5L→partner) and Y-score (partner→STXBP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT3_pY705 →	-0.146	-1.343	.019	.001	3	4
UCEC	Ku80 →	+0.158	+1.391	.025	.005	3	4
UCEC	JNK_pT183_Y185 →	-0.135	-1.584	.007	.017	3	3
COAD	GAPDH →	+0.514	+2.182	.024	.033	3	3
COAD	Caspase-7-cleavedD198 →	+1.067	+3.000	.002	.035	3	3
UCEC	Rab25 →	-0.275	-1.184	.005	.022	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

STAT3_pY705 by STXBP5L expression — SKCM

Explore this box plot interactively →