STXBP5L

Across TCGA cell cohorts, STXBP5L RNA expression is significantly associated with the go_rna of many other GO terms, with 2,118 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible STXBP5L-associated GO terms across cancer lineages are Cell cycle G1/S phase transition, Positive regulation of DNA repair, and Sister chromatid cohesion. Each is linked with STXBP5L in more than 9 cancer types. Because this analysis shows association rather than direction, both STXBP5L-to-partner and partner-to-STXBP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle G1/S phase transition grouped by STXBP5L-low versus STXBP5L-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP5L→partner) and Y-score (partner→STXBP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Cell cycle G1/S phase transition →	+0.064	+0.194	<.001	.004	2	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.057	+0.068	<.001	.003	3	9
SOFT_TISSUE	Sister chromatid cohesion →	+0.103	+0.202	<.001	.002	2	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of gene expression, epigenetic →	+0.052	+0.064	<.001	.005	3	8
BLOOD_Leukemia	Protein localization to nucleus →	+0.051	+0.595	<.001	.003	2	9
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA repair →	+0.052	+0.066	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,118 associations by consensus.

Cell cycle G1/S phase transition by STXBP5L expression — SOFT_TISSUE

Explore this box plot interactively →