STXBP5L

Across TCGA cell cohorts, STXBP5L mutation is significantly associated with the RNA expression of many other genes, with 160 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible STXBP5L-associated genes across cancer lineages are OR2B2, TAS2R7, and IMPACT. Each is linked with STXBP5L in more than 1 cancer types. Because this analysis shows association rather than direction, both STXBP5L-to-partner and partner-to-STXBP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2B2 grouped by STXBP5L-low versus STXBP5L-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP5L→partner) and Y-score (partner→STXBP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2B2 →	+0.052	+3.882	<.001	.004	3	2
LUNG_NSCLC_LUAD	TAS2R7 →	+0.018	+2.927	<.001	<.001	3	2
LUNG_NSCLC_LUAD	IMPACT →	-0.563	-3.215	.008	.005	3	2
LARGE_INTESTINE	TKTL2 →	+0.047	+2.924	<.001	.002	3	2
LARGE_INTESTINE	OR1C1 →	+0.041	+2.514	.001	.007	3	2
SOFT_TISSUE	TREML2 →	+0.098	+3.969	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 160 associations by consensus.

OR2B2 by STXBP5L expression — SOFT_TISSUE

Explore this box plot interactively →