STXBP5L

Across TCGA cell cohorts, STXBP5L mutation is significantly associated with the mutation status of many other genes, with 4,104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STXBP5L-associated genes across cancer lineages are CSMD1, IGSF1, and LRP1B. Each is linked with STXBP5L in more than 5 cancer types. Because this analysis shows association rather than direction, both STXBP5L-to-partner and partner-to-STXBP5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSMD1 grouped by STXBP5L-low versus STXBP5L-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP5L→partner) and Y-score (partner→STXBP5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CSMD1 →	+1.222	+1.874	.007	.007	1	6
SOFT_TISSUE	IGSF1 →	+4.777	+3.651	.002	.002	1	5
SOFT_TISSUE	LRP1B →	+2.385	+2.862	.009	.009	1	5
BLOOD_Leukemia	GRID2 →	+2.845	+3.209	.003	.003	1	5
LARGE_INTESTINE	GPR158 →	+2.301	+3.108	<.001	<.001	1	5
LARGE_INTESTINE	AMER3 →	+1.886	+2.189	.007	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,104 associations by consensus.

CSMD1 by STXBP5L expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →