STXBP5

Across TCGA pan-cancer cohorts, STXBP5 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated STXBP5 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STXBP5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STXBP5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

HNSC, UCEC, and KICH are the cancer types where STXBP5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.187	0.714	<.001	24	view →
UCEC	DFS	Median	All	0.978	0.825	.006	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
SCLC	OS	Median	III,IV	0.274	0.645	.027	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ACC	DFS	Median	II,III,IV	0.226	0.725	.009	6	view →
BLCA	DFS	Median	All	0.197	0.601	.009	6	view →
READ	DFS	Median	IV	0.255	0.628	.020	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →
SKCM	DFS	Median	All	0.471	0.190	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

STXBP5–HNSC (OS)

Open the HNSC breakdown →