STXBP4

Across TCGA pan-cancer cohorts, STXBP4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated STXBP4 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STXBP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated STXBP4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where STXBP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.394	0.805	.002	18	view →
LUAD	OS	Quartile	II,III,IV	0.821	0.301	.003	13	view →
CCRCC	DFS	Tertile	II,III,IV	0.418	0.837	.008	12	view →
GBM	OS	Tertile	All	0.640	0.453	.015	7	view →
LSCC	DFS	Tertile	II,III,IV	0.796	0.546	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

STXBP4–HNSC (DFS)

Open the HNSC breakdown →