STXBP4

Across TCGA patient cohorts, STXBP4 mutation is significantly associated with the RNA expression of many other genes, with 2,447 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP4-associated genes across cancer lineages are LCEP1, DPM2, and ASB6. Each is linked with STXBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STXBP4-to-partner and partner-to-STXBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCEP1 grouped by STXBP4-low versus STXBP4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP4→partner) and Y-score (partner→STXBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LCEP1 →	+0.079	+7.930	<.001	.008	3	2
SKCM	DPM2 →	+0.429	+2.706	.007	.003	3	2
SKCM	ASB6 →	+0.452	+2.706	.001	.003	3	2
UCEC	NTMT1 →	+0.580	+2.186	<.001	.001	3	2
SKCM	BRCC3P1 →	+0.205	+3.397	.004	.004	3	2
SKCM	HSPD1P12 →	+0.082	+2.237	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,447 associations by consensus.

LCEP1 by STXBP4 expression — LUAD

Explore this box plot interactively →