STX8

Across TCGA patient cohorts, STX8 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX8-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with STX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX8-to-partner and partner-to-STX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by STX8-low versus STX8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX8→partner) and Y-score (partner→STX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.118	-2.973	.007	.035	3	1
UCEC	eEF2 →	+0.440	+2.115	.004	.019	3	1
UCEC	EGFR_pY1068 →	-0.313	-2.584	.004	.010	3	1
UCEC	A-Raf_pS299 →	-0.150	-3.169	.003	.019	3	1
UCEC	ERK2 →	+0.214	+2.999	.011	.035	3	1
UCEC	ACC1 →	+0.366	+3.013	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

14-3-3_beta by STX8 expression — UCEC

Explore this box plot interactively →