STX5

Across TCGA pan-cancer cohorts, STX5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STX5 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STX5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated STX5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where STX5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	1.000	0.413	.033	5	view →
GBM	DFS	Median	All	0.822	0.684	.016	4	view →
CCRCC	DFS	Quartile	II,III,IV	0.384	0.743	.036	4	view →
UCEC	DFS	Median	All	0.954	0.858	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STX5–HNSC (DFS)

Open the HNSC breakdown →