STX5

Across TCGA patient cohorts, STX5 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX5-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and p62 Lck ligand. Each is linked with STX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX5-to-partner and partner-to-STX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by STX5-low versus STX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX5→partner) and Y-score (partner→STX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.277	+2.321	.010	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.768	+2.827	.009	.035	3	2
UCEC	p62 Lck ligand →	+0.381	+2.179	.019	.034	3	1
UCEC	Annexin-1 →	+0.548	+2.827	.038	.035	3	1
UCEC	TFRC →	+0.551	+2.321	.038	.035	3	1
UCEC	ATM →	-0.702	-3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PCNA by STX5 expression — UCEC

Explore this box plot interactively →