STX5

Across TCGA cell cohorts, STX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,494 significant associations in total. BONE shows the largest number of these associations.

The most reproducible STX5-associated GO terms across cancer lineages are Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, Endoplasmic reticulum to cytosol transport, and Retrograde protein transport, ER to cytosol. Each is linked with STX5 in more than 17 cancer types. Because this analysis shows association rather than direction, both STX5-to-partner and partner-to-STX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway grouped by STX5-low versus STX5-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STX5→partner) and Y-score (partner→STX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.175	+1.084	<.001	<.001	3	18
BONE	Endoplasmic reticulum to cytosol transport →	+0.160	+0.833	<.001	<.001	3	16
BONE	Retrograde protein transport, ER to cytosol →	+0.160	+0.833	<.001	<.001	3	16
STOMACH	Autophagy of mitochondrion →	+0.100	+0.785	.001	.004	3	16
STOMACH	Golgi vesicle transport →	+0.091	+1.071	<.001	<.001	3	16
BONE	Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.114	+0.614	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,494 associations by consensus.

Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway by STX5 expression — SOFT_TISSUE

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