STX4

Across TCGA pan-cancer cohorts, STX4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STX4 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher STX4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated STX4 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and HNSC are the cancer types where STX4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	1.000	0.890	.039	12	view →
LSCC	DFS	Tertile	III,IV	0.970	0.415	.019	5	view →
HNSC	OS	Median	II,III,IV	0.824	0.651	.035	4	view →
LUAD	DFS	Tertile	II,III,IV	0.283	0.703	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STX4–COAD (DFS)

Open the COAD breakdown →