STX4

Across TCGA pan-cancer cohorts, STX4 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of STX4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where STX4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types STX4 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, CCRCC, and LUAD are the cancer types where STX4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STX4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.211	<.001	9	view →
CCRCC	Male	III,IV	+0.211	<.001	6	view →
LUAD	Male	All	−0.142	<.001	6	view →
LSCC	All	All	−0.106	<.001	4	view →
OV	All	All	−0.255	.004	2	view →
PDAC	Male	All	−0.225	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

STX4–COAD

Open the COAD breakdown →