STX4

Across TCGA patient cohorts, STX4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX4-associated genes across cancer lineages are MEK1, p62 Lck ligand, and Caspase-7-cleavedD198. Each is linked with STX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX4-to-partner and partner-to-STX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by STX4-low versus STX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX4→partner) and Y-score (partner→STX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.574	+3.169	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.393	+2.710	.002	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.722	+2.019	.001	.017	3	2
UCEC	Caspase-8 →	-0.211	-2.673	.033	.005	3	2
UCEC	14-3-3_beta →	-0.102	-2.295	.009	.033	3	1
UCEC	eIF4E →	+0.194	+3.335	.019	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MEK1 by STX4 expression — UCEC

Explore this box plot interactively →