STX4

Across TCGA cell cohorts, STX4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STX4-associated genes across cancer lineages are TFDP3, SPEM2, and CENPVL1. Each is linked with STX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX4-to-partner and partner-to-STX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by STX4-low versus STX4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX4→partner) and Y-score (partner→STX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFDP3 →	+0.031	+3.196	<.001	.007	3	1
LARGE_INTESTINE	SPEM2 →	+0.058	+3.726	<.001	.004	3	1
LARGE_INTESTINE	CENPVL1 →	+0.150	+3.510	<.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.281	+3.196	<.001	.007	3	1
LARGE_INTESTINE	F11 →	+0.054	+3.882	<.001	.001	3	1
LARGE_INTESTINE	VAX1 →	+0.875	+3.519	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

TFDP3 by STX4 expression — LARGE_INTESTINE

Explore this box plot interactively →