STX3

Across TCGA patient cohorts, STX3 mutation is significantly associated with the RNA expression of many other genes, with 4,400 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX3-associated genes across cancer lineages are RNA5SP412, RNU6-893P, and RNA5SP417. Each is linked with STX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX3-to-partner and partner-to-STX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by STX3-low versus STX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX3→partner) and Y-score (partner→STX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.479	+1.797	<.001	.005	3	2
CESC	RNU6-893P →	+0.427	+4.193	.003	.009	3	2
CESC	RNA5SP417 →	+0.485	+5.837	<.001	.001	3	2
CESC	RNU6-362P →	+0.332	+6.584	<.001	<.001	3	2
CESC	PRAMEF13 →	+0.104	+6.584	<.001	<.001	3	2
LUAD	RNU6-1292P →	+0.347	+6.216	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,400 associations by consensus.

RNA5SP412 by STX3 expression — UCEC

Explore this box plot interactively →