STX3

Across TCGA patient cohorts, STX3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX3-associated genes across cancer lineages are PCNA, EGFR_pY1068, and eIF4E. Each is linked with STX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX3-to-partner and partner-to-STX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by STX3-low versus STX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX3→partner) and Y-score (partner→STX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.203	+1.678	.014	.023	3	2
UCEC	EGFR_pY1068 →	-0.228	-2.087	.018	.005	3	1
UCEC	eIF4E →	+0.258	+3.906	.001	<.001	3	1
UCEC	FASN →	+0.451	+3.169	.002	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.135	-2.212	.004	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.176	-2.584	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PCNA by STX3 expression — UCEC

Explore this box plot interactively →