STX2

Across TCGA patient cohorts, STX2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX2-associated genes across cancer lineages are Notch1, EGFR_pY1068, and eIF4E. Each is linked with STX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX2-to-partner and partner-to-STX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by STX2-low versus STX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX2→partner) and Y-score (partner→STX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.182	+1.765	<.001	.014	3	2
UCEC	EGFR_pY1068 →	-0.233	-1.700	.013	.042	3	1
UCEC	eIF4E →	+0.198	+3.472	.012	.002	3	1
UCEC	A-Raf_pS299 →	-0.100	-3.169	.026	.018	3	1
UCEC	FoxM1 →	+0.242	+1.916	.012	.009	3	1
UCEC	FOXO3a_pS318_S321 →	-0.152	-2.700	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Notch1 by STX2 expression — UCEC

Explore this box plot interactively →