STX2

Across TCGA cell cohorts, STX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,736 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STX2-associated GO terms across cancer lineages are Microtubule polymerization or depolymerization, Microtubule polymerization, and Protein localization to non-motile cilium. Each is linked with STX2 in more than 13 cancer types. Because this analysis shows association rather than direction, both STX2-to-partner and partner-to-STX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule polymerization or depolymerization grouped by STX2-low versus STX2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STX2→partner) and Y-score (partner→STX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Microtubule polymerization or depolymerization →	+0.097	+1.533	<.001	<.001	3	14
BREAST	Microtubule polymerization →	+0.096	+1.564	<.001	<.001	3	14
LUNG_NSCLC_LUAD	Protein localization to non-motile cilium →	+0.079	+1.325	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Regulation of cytokinesis →	+0.087	+1.888	.001	<.001	3	13
BREAST	Regulation of metaphase/anaphase transition of cell cycle →	+0.106	+1.521	.001	<.001	3	13
URINARY_TRACT	Protein localization to cilium →	+0.067	+2.076	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,736 associations by consensus.

Microtubule polymerization or depolymerization by STX2 expression — BREAST

Explore this box plot interactively →