STX1A

Across TCGA pan-cancer cohorts, STX1A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STX1A data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher STX1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STX1A expression acts as an unfavorable survival marker.

LIHC, PRAD, and UCEC are the cancer types where STX1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.025	0.777	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STX1A–LIHC (OS)

Open the LIHC breakdown →