STX1A

Across TCGA pan-cancer cohorts, STX1A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated STX1A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher STX1A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated STX1A expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, HNSC, and GBM are the cancer types where STX1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	III,IV	1.000	0.407	.010	9	view →
HNSC	DFS	Median	III,IV	0.582	0.988	.018	2	view →
GBM	DFS	Quartile	All	0.856	0.641	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

STX1A–PDAC (OS)

Open the PDAC breakdown →