STX17

Across TCGA patient cohorts, STX17 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX17-associated genes across cancer lineages are Annexin-1, STAT3_pY705, and c-Kit. Each is linked with STX17 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX17-to-partner and partner-to-STX17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by STX17-low versus STX17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX17→partner) and Y-score (partner→STX17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.616	+3.189	.012	.010	3	1
UCEC	STAT3_pY705 →	-0.376	-3.169	.002	.018	3	1
UCEC	c-Kit →	-0.224	-3.439	.039	.005	3	1
UCEC	FoxM1 →	+0.254	+2.817	.035	.036	2	1
UCEC	mTOR →	-0.295	-3.459	<.001	.005	2	1
UCEC	p62 Lck ligand →	+0.379	+3.331	.012	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Annexin-1 by STX17 expression — UCEC

Explore this box plot interactively →