STX16

Across TCGA pan-cancer cohorts, STX16 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated STX16 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher STX16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STX16 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

KIRC, LIHC, and LGG are the cancer types where STX16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.513	0.707	<.001	142	view →
LIHC	DFS	Tertile	All	0.432	0.622	<.001	101	view →
LGG	DFS	Median	All	0.661	0.811	<.001	50	view →
SKCM	OS	Quartile	III,IV	0.550	0.241	.002	49	view →
ACC	DFS	Quartile	All	0.247	0.871	.001	36	view →
COAD	DFS	Tertile	All	0.591	0.807	.002	33	view →
UCS	DFS	Tertile	IV	0.996	0.360	.024	30	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	30	view →
READ	OS	Tertile	IV	1.000	0.535	.008	26	view →
KIRP	DFS	Tertile	III,IV	0.122	0.675	.005	23	view →
UCEC	DFS	Quartile	All	0.792	0.886	.017	20	view →
PRAD	DFS	Median	All	0.839	0.927	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

STX16–KIRC (DFS)

Open the KIRC breakdown →