STX12

Across TCGA pan-cancer cohorts, STX12 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STX12 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STX12 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated STX12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LSCC are the cancer types where STX12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.802	0.625	.014	17	view →
UCEC	DFS	Tertile	All	0.986	0.879	.038	6	view →
LSCC	DFS	Tertile	II,III,IV	0.552	0.896	.018	6	view →
GBM	DFS	Tertile	All	0.290	0.494	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STX12–HNSC (OS)

Open the HNSC breakdown →