STX12

Across TCGA patient cohorts, STX12 mutation is significantly associated with the RNA expression of many other genes, with 371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX12-associated genes across cancer lineages are RNU6-183P, RNU6-1181P, and TXNL4AP1. Each is linked with STX12 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX12-to-partner and partner-to-STX12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-183P grouped by STX12-low versus STX12-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX12→partner) and Y-score (partner→STX12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-183P →	+0.328	+5.303	.001	.006	3	2
HNSC	RNU6-1181P →	+0.524	+6.008	<.001	.002	3	2
HNSC	TXNL4AP1 →	+0.112	+5.069	<.001	.008	3	2
BLCA	RN7SKP204 →	+0.300	+5.411	<.001	.005	3	2
SKCM	RNU6-709P →	+0.483	+7.816	<.001	.008	3	2
UCEC	TXNDC11 →	+0.412	+3.483	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 371 associations by consensus.

RNU6-183P by STX12 expression — HNSC

Explore this box plot interactively →