STX12

Across TCGA patient cohorts, STX12 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX12-associated genes across cancer lineages are ATM, ERK2, and MEK1. Each is linked with STX12 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX12-to-partner and partner-to-STX12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by STX12-low versus STX12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX12→partner) and Y-score (partner→STX12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.679	-3.584	.001	.002	3	2
UCEC	ERK2 →	+0.233	+2.459	.012	.020	3	1
UCEC	MEK1 →	+0.464	+3.169	.008	.019	3	1
UCEC	Rab25 →	-0.369	-2.459	.021	.020	3	1
UCEC	Raptor →	-0.157	-2.999	.032	.035	3	1
UCEC	Annexin-1 →	+0.665	+3.019	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ATM by STX12 expression — UCEC

Explore this box plot interactively →