STX11

Across TCGA patient cohorts, STX11 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX11-associated genes across cancer lineages are Cyclin-B1, eIF4E, and ERK2. Each is linked with STX11 in more than 2 cancer types. Because this analysis shows association rather than direction, both STX11-to-partner and partner-to-STX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by STX11-low versus STX11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX11→partner) and Y-score (partner→STX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.684	+2.169	.001	.003	3	3
COAD	eIF4E →	+0.322	+3.012	<.001	.018	3	2
UCEC	ERK2 →	+0.182	+1.415	.011	.046	3	2
UCEC	GATA6 →	-0.124	-1.899	.046	.016	3	2
UCEC	Rab25 →	-0.323	-1.415	.009	.046	3	2
UCEC	ASNS →	+0.324	+1.765	.017	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Cyclin-B1 by STX11 expression — UCEC

Explore this box plot interactively →