STX10

Across TCGA patient cohorts, STX10 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STX10-associated genes across cancer lineages are MIR6715A, RNA5SP148, and TRGJ1. Each is linked with STX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX10-to-partner and partner-to-STX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6715A grouped by STX10-low versus STX10-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX10→partner) and Y-score (partner→STX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6715A →	+0.276	+7.731	<.001	.009	3	1
BRCA	RNA5SP148 →	+0.234	+7.731	.001	.009	3	1
BRCA	TRGJ1 →	+0.468	+8.471	<.001	.005	3	1
BRCA	RNA5SP482 →	+0.197	+7.731	<.001	.009	3	1
BRCA	RBM22P7 →	+0.109	+9.057	<.001	.003	3	1
BRCA	RNA5SP182 →	+1.228	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MIR6715A by STX10 expression — BRCA

Explore this box plot interactively →