STX10

Across TCGA cell cohorts, STX10 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STX10-associated genes across cancer lineages are VWC2L, PRAMEF12, and MAGEB4. Each is linked with STX10 in more than 1 cancer types. Because this analysis shows association rather than direction, both STX10-to-partner and partner-to-STX10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by STX10-low versus STX10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STX10→partner) and Y-score (partner→STX10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWC2L →	+0.010	+4.339	<.001	.002	3	2
LARGE_INTESTINE	PRAMEF12 →	+0.099	+4.977	<.001	.007	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	FTHL17 →	+0.067	+5.415	<.001	.004	3	1
LARGE_INTESTINE	GOT1L1 →	+0.046	+6.022	<.001	.001	3	1
LARGE_INTESTINE	ZNF366 →	+0.039	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

VWC2L by STX10 expression — BLOOD_Leukemia

Explore this box plot interactively →