Across TCGA pan-cancer cohorts, STUM RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of STUM’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where STUM RNA is repressed in tumor relative to normal tissue. In most cancer types STUM is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.
BLCA, COAD, and THCA are the cancer types where STUM tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STUM RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.