STS

Across TCGA pan-cancer cohorts, STS Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated STS data layer compared with 24 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher STS Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STS expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and BLCA are the cancer types where STS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.526	0.857	<.001	39	view →
UCEC	DFS	Median	II,III,IV	0.896	0.299	.007	20	view →
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
LIHC	OS	Median	II,III,IV	0.033	0.716	<.001	12	view →
LUSC	DFS	Median	II,III,IV	0.217	0.594	.045	4	view →
SKCM	DFS	Median	III,IV	0.111	0.654	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

STS–COAD (OS)

Open the COAD breakdown →