STS

Across TCGA patient cohorts, STS mutation is significantly associated with the RNA expression of many other genes, with 3,433 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STS-associated genes across cancer lineages are OIP5, RNU6-1126P, and C18orf32. Each is linked with STS in more than 2 cancer types. Because this analysis shows association rather than direction, both STS-to-partner and partner-to-STS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by STS-low versus STS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STS→partner) and Y-score (partner→STS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.739	+1.938	<.001	<.001	3	3
LUAD	RNU6-1126P →	+0.306	+4.859	<.001	.004	3	3
UCEC	C18orf32 →	+0.356	+1.754	<.001	<.001	3	3
UCEC	TIMM21 →	+0.415	+1.928	<.001	<.001	3	3
UCEC	RPL17P50 →	+0.487	+1.938	<.001	<.001	3	3
UCEC	TCERG1L-AS1 →	+0.211	+1.709	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,433 associations by consensus.

OIP5 by STS expression — UCEC

Explore this box plot interactively →