STS

Across TCGA patient cohorts, STS mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STS-associated genes across cancer lineages are Notch1, SF2, and GAPDH. Each is linked with STS in more than 2 cancer types. Because this analysis shows association rather than direction, both STS-to-partner and partner-to-STS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by STS-low versus STS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STS→partner) and Y-score (partner→STS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.105	+2.100	.012	.002	3	3
SKCM	SF2 →	-0.154	-2.321	.025	.035	3	2
UCEC	GAPDH →	+0.390	+1.678	.014	.021	3	2
UCEC	MSH6 →	-0.274	-1.237	.005	.041	3	2
UCEC	PDCD4 →	-0.302	-1.184	.031	.022	3	2
UCEC	VHL →	-0.542	-1.514	.007	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Notch1 by STS expression — UCEC

Explore this box plot interactively →