STS

Across TCGA cell cohorts, STS RNA expression is significantly associated with the go_rna of many other GO terms, with 5,033 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STS-associated GO terms across cancer lineages are Vacuole organization, Small GTPase-mediated signal transduction, and Rho protein signal transduction. Each is linked with STS in more than 9 cancer types. Because this analysis shows association rather than direction, both STS-to-partner and partner-to-STS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuole organization grouped by STS-low versus STS-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STS→partner) and Y-score (partner→STS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Vacuole organization →	+0.050	+1.398	.007	.001	2	10
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.043	+1.713	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Rho protein signal transduction →	+0.128	+1.438	<.001	<.001	3	9
KIDNEY	Endosome to lysosome transport →	+0.055	+0.542	.003	.008	2	9
CNS	Positive regulation of leukocyte differentiation →	+0.062	+1.004	<.001	<.001	3	8
BONE	Regulation of protein localization to plasma membrane →	+0.079	+1.075	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,033 associations by consensus.

Vacuole organization by STS expression — BONE

Explore this box plot interactively →