STS

Across TCGA cell cohorts, STS mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STS-associated genes across cancer lineages are GPHB5, SCYGR8, and MYOT. Each is linked with STS in more than 1 cancer types. Because this analysis shows association rather than direction, both STS-to-partner and partner-to-STS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPHB5 grouped by STS-low versus STS-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STS→partner) and Y-score (partner→STS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPHB5 →	+0.039	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	SCYGR8 →	+0.022	+5.662	<.001	.002	3	1
LARGE_INTESTINE	MYOT →	+0.091	+3.453	.008	.009	3	1
LARGE_INTESTINE	SEMG2 →	+0.470	+3.878	.002	.003	3	1
LARGE_INTESTINE	DCSTAMP →	+0.130	+3.936	<.001	.002	3	1
LARGE_INTESTINE	HTR1E →	+0.074	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GPHB5 by STS expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →