STRN4

Across TCGA patient cohorts, STRN4 mutation is significantly associated with the RNA expression of many other genes, with 2,457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRN4-associated genes across cancer lineages are TRIM64EP, ENO2, and OTX1. Each is linked with STRN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both STRN4-to-partner and partner-to-STRN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM64EP grouped by STRN4-low versus STRN4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRN4→partner) and Y-score (partner→STRN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	TRIM64EP →	+0.018	+4.384	.005	.008	3	3
UCEC	ENO2 →	+0.817	+2.169	.001	.003	3	3
UCEC	OTX1 →	+0.710	+2.447	.002	.001	3	3
STAD	TMEM191A →	+0.855	+3.359	<.001	.004	3	3
UCEC	HPGDS →	-0.429	-3.584	.002	.002	3	3
STAD	ZNF511 →	+0.649	+3.338	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,457 associations by consensus.

TRIM64EP by STRN4 expression — CESC

Explore this box plot interactively →