STRN4

Across TCGA patient cohorts, STRN4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRN4-associated genes across cancer lineages are MSH2, STAT3_pY705, and Tuberin_pT1462. Each is linked with STRN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STRN4-to-partner and partner-to-STRN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by STRN4-low versus STRN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRN4→partner) and Y-score (partner→STRN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.352	-3.295	<.001	.009	3	2
UCEC	STAT3_pY705 →	-0.299	-3.449	.005	.005	3	2
UCEC	Tuberin_pT1462 →	+0.211	+2.331	.027	.019	3	2
UCEC	ATM →	-0.685	-2.321	<.001	.006	3	2
UCEC	eIF4E →	+0.187	+2.459	.032	.019	3	1
UCEC	ERK2 →	+0.178	+1.807	.025	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MSH2 by STRN4 expression — UCEC

Explore this box plot interactively →