Across TCGA patient cohorts, STRN3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRN3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FoxM1. Each is linked with STRN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STRN3-to-partner and partner-to-STRN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRN3→partner) and Y-score (partner→STRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.269	-1.662	.002	.011	3	2
UCEC	eIF4E →	+0.151	+2.335	.043	.018	3	2
UCEC	FoxM1 →	+0.220	+2.000	.016	.003	3	2
UCEC	Heregulin →	-0.105	-2.000	.016	.003	3	2
UCEC	PCNA →	+0.221	+2.392	.003	<.001	3	2
UCEC	S6_pS240_S244 →	+0.375	+3.472	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

STRN3 survival (RNA) · tumor vs normal (RNA) · all STRN3 data types