STRN

Across TCGA patient cohorts, STRN mutation is significantly associated with the RNA expression of many other genes, with 3,400 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRN-associated genes across cancer lineages are AIMP1, BBC3, and RAI1. Each is linked with STRN in more than 2 cancer types. Because this analysis shows association rather than direction, both STRN-to-partner and partner-to-STRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AIMP1 grouped by STRN-low versus STRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRN→partner) and Y-score (partner→STRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AIMP1 →	+0.398	+2.169	.001	.009	3	3
SKCM	BBC3 →	+0.769	+2.813	<.001	.001	3	3
UCEC	RAI1 →	+0.739	+2.148	<.001	<.001	3	3
UCEC	ZNF330 →	+0.434	+3.021	<.001	<.001	3	3
UCEC	GOT1 →	+0.393	+2.587	.001	<.001	3	3
SKCM	EXOSC9 →	+0.526	+2.813	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,400 associations by consensus.

AIMP1 by STRN expression — UCEC

Explore this box plot interactively →