STRN

Across TCGA patient cohorts, STRN mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRN-associated genes across cancer lineages are c-Met_pY1235, eIF4E, and 53BP1. Each is linked with STRN in more than 1 cancer types. Because this analysis shows association rather than direction, both STRN-to-partner and partner-to-STRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by STRN-low versus STRN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRN→partner) and Y-score (partner→STRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Met_pY1235 →	+0.133	+3.169	.003	.019	3	2
UCEC	eIF4E →	+0.189	+2.700	.019	.006	3	2
UCEC	53BP1 →	+0.331	+3.321	.011	.009	3	2
SKCM	Cyclin-D1 →	-0.254	-3.169	.034	.019	3	1
UCEC	14-3-3_beta →	-0.094	-2.558	.014	.010	3	1
UCEC	eIF4G →	+0.283	+2.999	.017	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

c-Met_pY1235 by STRN expression — SKCM

Explore this box plot interactively →