STRN

Across TCGA cell cohorts, STRN mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STRN-associated genes across cancer lineages are CCL18, LGI1, and USP29. Each is linked with STRN in more than 1 cancer types. Because this analysis shows association rather than direction, both STRN-to-partner and partner-to-STRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL18 grouped by STRN-low versus STRN-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRN→partner) and Y-score (partner→STRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCL18 →	+0.045	+4.212	<.001	.007	3	1
BLOOD_Leukemia	LGI1 →	+0.122	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRT71 →	+0.066	+4.922	<.001	.009	3	1
LARGE_INTESTINE	KCNK17 →	+0.083	+3.466	<.001	.009	3	1
LARGE_INTESTINE	CR1L →	+0.039	+3.196	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CCL18 by STRN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →