STRN

Across TCGA cell cohorts, STRN mutation is significantly associated with the mutation status of many other genes, with 2,290 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STRN-associated genes across cancer lineages are CDH18, PKD1L1, and TAF6. Each is linked with STRN in more than 3 cancer types. Because this analysis shows association rather than direction, both STRN-to-partner and partner-to-STRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH18 grouped by STRN-low versus STRN-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRN→partner) and Y-score (partner→STRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDH18 →	+2.245	+3.959	.005	.005	1	4
SKIN	PKD1L1 →	+2.146	+3.860	.007	.007	1	4
SKIN	TAF6 →	+5.053	+4.239	.007	.007	1	4
LUNG_NSCLC_LUAD	PTPRC →	+3.602	+4.851	.002	.002	1	4
BLOOD_Leukemia	LAMA4 →	+2.779	+4.326	.006	.006	1	3
BLOOD_Leukemia	INO80D →	+3.309	+4.794	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,290 associations by consensus.

CDH18 by STRN expression — SKIN

Explore this box plot interactively →