STRIP2

Across TCGA pan-cancer cohorts, STRIP2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated STRIP2 data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STRIP2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated STRIP2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where STRIP2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.145	0.682	<.001	36	view →
LUAD	OS	Median	All	0.068	0.788	<.001	18	view →
UCEC	DFS	Median	All	0.965	0.611	.007	12	view →
COAD	OS	Median	IV	0.056	0.659	.002	9	view →
LUSC	OS	Median	All	0.873	0.386	.006	9	view →
SKCM	DFS	Median	III,IV	0.192	0.652	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

STRIP2–HNSC (DFS)

Open the HNSC breakdown →