STRIP2

Across TCGA patient cohorts, STRIP2 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRIP2-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and eIF4E. Each is linked with STRIP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STRIP2-to-partner and partner-to-STRIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by STRIP2-low versus STRIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRIP2→partner) and Y-score (partner→STRIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.804	+3.107	<.001	<.001	3	3
UCEC	C-Raf →	+0.156	+2.321	.001	.005	3	3
UCEC	eIF4E →	+0.198	+2.070	.006	.001	3	2
COAD	FASN →	+0.481	+3.330	.008	.005	3	2
UCEC	Heregulin →	-0.106	-1.415	.013	.043	3	2
UCEC	mTOR_pS2448 →	-0.154	-2.070	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Caspase-7-cleavedD198 by STRIP2 expression — UCEC

Explore this box plot interactively →