STRIP2

Across TCGA cell cohorts, STRIP2 mutation is significantly associated with the RNA expression of many other genes, with 304 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STRIP2-associated genes across cancer lineages are SIGLEC8, MRGPRX2, and ADAM2. Each is linked with STRIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STRIP2-to-partner and partner-to-STRIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by STRIP2-low versus STRIP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRIP2→partner) and Y-score (partner→STRIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC8 →	+0.010	+2.760	<.001	.003	3	2
BREAST	MRGPRX2 →	+0.023	+4.199	<.001	.007	3	2
PANCREAS	ADAM2 →	+0.022	+5.000	<.001	.006	3	1
PANCREAS	RPS4Y2 →	+0.026	+5.000	<.001	.006	3	1
LARGE_INTESTINE	MCAT →	+0.626	+3.212	.004	.006	3	1
LARGE_INTESTINE	AVP →	+0.037	+3.047	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 304 associations by consensus.

SIGLEC8 by STRIP2 expression — LARGE_INTESTINE

Explore this box plot interactively →